Investigation of\nthe Antibacterial Properties of Janus\nMicromotors Catalytic Propelled by Manganese Dioxide and Hydrogen\nPeroxide to Reduce Bacterial Density

Between 2015 and 2017, 90% of Chinese adults were reported\nto have\nperiodontitis of varying degrees, highlighting the importance of novel,\ninexpensive, and affordable treatments for the public. The fact that\nmore and more pathogens are becoming resistant to antibiotics further\nhighlights this prevalence. This article addresses a novel micromotor\ncapable of generating reactive oxygen species, as proven by a Fenton-like\nreaction. Such reactions allow the targeting of Gram-negative bacteria\nsuch as Escherichia coli, which are\neliminated order of magnitude more effectively than by pure hydrogen\nperoxide, thereby addressing pathogens relevant in oral infections.\nThe basis of the micromotors, which generate reactive oxygen species\non site, reduces the likelihood of resistance developing in these\ntypes of bacteria. Catalytically reducing hydrogen peroxide in this\nprocess, these micromotors propel themselves forward. This proof of\nprinciple study paves the way for the utilization of micromotors in\nthe field of skin disinfection utilizing hydrogen peroxide concentrations\nwhich were in previous works proven noncytotoxic.