Chinese Yam-Derived\nAdhesive Microgel for Effective\nManagement of Uncontrolled Hemorrhage and Trauma-Induced Skin Wounds

Chinese yam (Dioscorea opposita),\na traditional medicinal plant, has gained renewed interest in contemporary\nresearch due to its broad therapeutic potential. In this study, we\ndeveloped an adhesive yam microgel through a series of peeling, grinding,\nsieving, and rehydration processes. Our in vitro experiments demonstrated\nthat the yam microgel was noncytotoxic, effectively scavenged free\nradicals, and promoted cell migration. Additionally, the microgels\nexhibit good blood compatibility and biodegradability. In vivo, we\nfirst evaluated the hemostatic properties of the yam microgel in different\nhemorrhage models in rats. It demonstrated strong hemostatic capabilities\nbecause it could adsorb many blood cells and platelets, activate platelets,\nand facilitate coagulation. Furthermore, we observed that the yam\nmicrogel promotes the repair of acute skin tissue defects by enhancing\ncell proliferation and neovascularization as well as modulating the\ninflammatory response, thereby accelerating wound healing. Finally,\nwe found that the yam microgel can serve as a biological adhesive,\neffectively promoting wound closure through a mechanism similar to\nits role in facilitating skin tissue repair. The design of a low-cost,\nsafe, and effective yam microgel will provide a promising strategy\nfor hemostasis and wound healing.