Engineering\nSurface-Adaptive Metal–Organic\nFramework Armor to Promote Infected Wound Healing

Metal–organic\nframeworks (MOFs) hold enormous promise for\ntreating bacterial infections to circumvent the threat of antibiotic\nresistance. However, positioning MOFs on wound dressings is hindered\nand remains a significant challenge. Herein, a facile heterointerfacial\nengineering strategy was developed to tailor the “MOF armor”\nthat adaptively weaponized the poly(ε-caprolactone) electrospun\ndressing with excellent bacteria-killing efficacy. Hydrophilic epitaxial\ncrystallization to enhance the interfacial wettability is the key\nto induce the uniform seeding of Cu<sup>2+</sup> and thus to generate\na compact MOF layer on the electrospun dressing. The universality\nof the proposed strategy was demonstrated by the construction of different\nkinds of MOFs (HKUST-1, ZIF-8, and ZIF-67) on variously shaped substrates\n(nanofibers, pellets, plates, and 3D-printed porous scaffolds). By\noptimizing the Cu<sup>2+</sup> loading, the Cu-MOF armor exhibited\nsustained ion release behavior, strong antibacterial activity, and\ngood biocompatibility. <i>In vivo</i> rat model revealed\nthat the Cu-MOF armor significantly promoted infected wound healing\nby inhibiting inflammatory factors, promoting collagen deposition,\nand angiogenesis. This unique MOF armor provides an appealing and\neffective solution for designing and fabricating advanced wound dressings.