Organocatalyzed\nEnantioselective Double Dearomatization\nof Tricyclic Phenols and Alkoxybenzenes

To advance more efficient dearomatization approaches,\nwe present\nherein an organocatalyzed asymmetric double dearomatization reaction\nof tricyclic phenols and alkoxybenzenes by leveraging a novel steric\nhindrance-regulated dearomatization strategy for nonfunctionalized\nphenols. This protocol allows the efficient synthesis of structurally\ncomplex polycyclic diketones with four tertiary carbon centers under\nmild conditions while also showcasing the potential of multiple dearomatizations\nfor building intricate molecular frameworks from simple starting materials