<i>N</i>‑(<i>para</i>-Methoxyphenylpropargyl)\nPyrrole-2-carboxylate (PPPC) Glycosides as Donors for Glycosylation

We\ndeveloped glycosyl <i>N</i>-(<i>para</i>-methoxyphenylpropargyl)\npyrrole-2-carboxylates (PPPCs) as highly\neffective donors for chemical glycosylation. The modular design and\nexceptional stability of the acid precursor provide PPPC donors with\nsynthetic versatility and ease of use. Activated by NIS/TMSOTf, PPPC\ndonors exhibit a broad compatibility for both <i>O</i>-\nand <i>N</i>-glycosylation reactions. Their distinct reactivity\ngradient enables streamlined one-pot syntheses, complementing thioglycosides\nand imidates. These features position PPPC donors as promising tools\nfor advancing carbohydrate chemistry.