Nigrosporinol\nSulfoxides A and B, Sulfur-Bridged Heterocyclic\nSesquiterpenoids Produced by Cultures of the Fungus <i>Nigrospora\nlacticolonia</i>

The sesquiterpenoids nigrosporinol sulfoxides A (<b>1</b>) and B (<b>2</b>) have been isolated from cultures\nof the\nendophytic fungus <i>Nigrospora lacticolonia</i> harvested\nfrom the sunchoke <i>Helianthus tuberosus</i> L. collected\nin Thailand. Nigrosporinol sulfoxides A (<b>1</b>) and B (<b>2</b>) have 4/5/5/5/7 heterocyclic skeletons <b>3</b> featuring\na sulfoxide bridge not previously found in a terpenoid natural product\nfrom any living source.