Organocatalytic\nStrategy for a Formal 1,6-Conjugate\nHydroxylation

Thanks to the versatile vinylogous hexafluoro <i>iso</i>-propyl acrylate molecular platforms, a regio- and enantioselective\nsulfa-Michael reaction was achieved upon organocatalytic conditions,\nallowing the subsequent amidation, one-pot oxidation, and Mislow-Bravermann-Evans\n[2,3]-sigmatropic rearrangement along with a 1,3-chirality transfer,\nleading eventually to a formal asymmetric 1,6-hydroxylation sequence.