A Continuous\nFlow Process for the Defluorosilylation\nof HFC-23 and HFO-1234yf

A continuous flow\nprocess has been developed for the defluorosilylation\nof trifluoromethane (HFC-23) and 2,3,3,3-tetrafluoropropene (HFO-1234yf)\nthrough reaction with lithium silanide reagents under inert conditions.\nDesign of experiment optimization improved process conditions, including\nproductivity, yields, reduction of solvent use, and gas destruction.\nThe small chain fluorinated organosilane products R<sub>3</sub>SiCF<sub>2</sub>H and R<sub>3</sub>SiCH<sub>2</sub>C(F)CF<sub>2</sub> were competent nucleophiles in the fluoride-catalyzed difluoromethylation\nof aldehydes, and trifluoroallylation of aldehydes, ketones, and imines.