Stereoselective\nAminomethylation of β,β-Disubstituted\nEnesulfinamides: Asymmetric Construction of Less Accessible Acyclic\nα,α-Disubstituted α‑Aminomethylated Ketimines

β,β-Disubstituted enesulfinamides undergo\nstereoselective\nnucleophilic addition to the formaldehyde imines, in situ formed from\ntosylmethylcarbamates, affording α-aminomethylated ketimines\nbearing a challenging acyclic quaternary stereocenter substituted\nby two sterically and electronically similar groups (e.g., Me and\nEt). The defined geometry of the CC bond in the enesulfinamides,\ncombined with the strong chiral induction offered by their chiral\nsulfinyl group, ensures precise stereocontrol during the formation\nof the new C–C bond.