Difunctionalizationof Alkenes toward 3,3-Disubstitutedand Dihydrobenzoindolines by Using an Imidazolylidene PalladacyclicCatalyst

The synthesis of valuable 2a,3-dihydrobenzo[<i>cd</i>]indolines was successfully achieved by combining IPr-Pd<sub>cycle</sub>-Oxa<sub>Naphthyl</sub>-catalyzed cross-coupling and proton-induced hydroarylation in a one-pot method. In situ-generated alkynyl-functionalized 3,3-disubstituted indolines were proved as the key intermediate, bearing a broad scope of substrates with diverse functional groups and electronic properties.

Publication Details

Journal
Figshare
Published
2025-03-07
DOI
https://doi.org/10.1021/acs.joc.4c03100.s001
Primary Topic
Catalytic C–H Functionalization Methods
Type
article
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article

Difunctionalizationof Alkenes toward 3,3-Disubstitutedand Dihydrobenzoindolines by Using an Imidazolylidene PalladacyclicCatalyst

Figshare
Catalytic C–H Functionalization Methods
article

Difunctionalizationof Alkenes toward 3,3-Disubstitutedand Dihydrobenzoindolines by Using an Imidazolylidene PalladacyclicCatalyst

article en

Abstract

The synthesis of valuable 2a,3-dihydrobenzo[<i>cd</i>]indolines was successfully achieved by combining IPr-Pd<sub>cycle</sub>-Oxa<sub>Naphthyl</sub>-catalyzed cross-coupling and proton-induced hydroarylation in a one-pot method. In situ-generated alkynyl-functionalized 3,3-disubstituted indolines were proved as the key intermediate, bearing a broad scope of substrates with diverse functional groups and electronic properties.

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Catalytic C–H Functionalization Methods
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Difunctionalizationof Alkenes toward 3,3-Disubstitutedand Dihydrobenzoindolines by Using an Imidazolylidene PalladacyclicCatalyst · Figshare (2025) | TGRS Research Map | TGRS