Total Synthesis\nand Structural Reassignment of the\nMolt-Inhibiting Marine Alkaloid Erebusinone

The\nmarine alkaloid erebusinone is a secondary metabolite isolated\nfrom the Antarctic sponge <i>Isodictya erinacea</i>. Initial\nbiological assays have shown that erebusinone increases amphipod mortality,\nprobably by inhibition of the biosynthesis of molting hormone (ecdysone).\nHerein, we report the first total synthesis of the proposed structure\nof erebusinone and a structural revision.