Divergent Synthesisof Diaza-oxabicyclo[3.2.1]octanesand Dioxa-azabicyclo[3.2.1]octanes via Cascade Cyclizations

Bicyclo­[3.2.1]­octanes widely exist in natural products and bioactive compounds. However, the efficient construction of these skeletons remains a challenge. Herein, we reported a convenient synthesis of diaza-oxabicyclo[3.2.1]­octanes and dioxa-azabicyclo[3.2.1]­octanes by intramolecular cascade cyclizations. The reaction was performed under transition metal-free conditions and with good functional group tolerance. This work provides divergent approaches to bicyclo[3.2.1]­octane frameworks.