B/Pd Synergistic Catalysis\nfor the Decarboxylative\nAllylation of 2‑(2-Azaaryl)acetic Acids

We\ndescribe an allylation reaction between 2-(2-azaaryl)acetic\nacids and allylic electrophiles catalyzed synergistically by a dual\nsystem consisting of borinic acid and a Pd complex under mild conditions.\nThe decarboxylative allylation proceeds via a boron-bound enamine\nintermediate, which then interacts with a π-allylpalladium intermediate\nfrom the allylic electrophile. High yields of diallylation products\nhighlight the method’s efficiency. Intriguingly, when using\n2-(2-pyridyl)acetic acid with a C3 substituent on the pyridyl ring,\nthe reaction exclusively yields monoallylation products.