In Situ-Generated\nFormamidine as a Carbon/Nitrogen\nSource for Enaminone Formation: One-Pot Synthesis of Functionalized\n4‑Acyl-1,2,3-triazoles

<i>N</i>,<i>N</i>-Dimethylformamide\nwas reacted\nwith hexamethyldisilazane to generate an <i>N</i>,<i>N</i>-dimethylformimidamide intermediate; thereafter, a reaction\nwith acetophenones/β-diketones was induced to form enaminones.\nThe one-pot synthetic protocol described in this paper can be applied\nto synthesize 1,4-disubstituted 1,2,3-triazoles and 1,4,5-trisubstituted\n1,2,3-triazoles, in which organic azides are used as substrates under\noptimized conditions. Furthermore, this protocol uses readily available\nmaterials, is nearly free of solvent, can be applied to gram-scale\noperations, and leads to the formation of structurally diverse products\nwith favorable yields.