Copper-Catalyzed\nAsymmetric Nucleophilic Substitutions\nof TsSCF<sub>3</sub>: Synthesis of Chiral SCF<sub>3</sub>‑Containing\nCompounds

By employing electrophilic TsSCF<sub>3</sub> as an efficient\nSCF<sub>3</sub> source, we reported Cu/<b>SOP</b> (chiral sulfoxide-phosphine\nligand)-catalyzed enantioselective nucleophilic substitutions. Under\nthis protocol, α-pyridyl-α-fluoro esters as latent carbon\nnucleophiles, compounds containing a C-SCF<sub>3</sub> stereocenter\nalong with azacycles and fluorine atoms, were obtained in good yields\nand enantioselectivities under mild conditions (up to 68% yield, 92%\nee).