One-Pot Synthesis\nof Chiral <i>Spiro</i>-Imidazolidinone Cyclohexenones

We have developed a simple and straightforward\nsynthesis\nof chiral <i>spiro</i>-imidazolidinone cyclohexenones, featuring\nsix contiguous\nstereocenters, from feedstock chemicals such as aminophenols, α,β-unsaturated\naldehydes, and α-amino acids. Remarkably, this one-pot multicomponent\nreaction exhibits exceptional diastereoselectivity (>20:1 dr) and\nrelies solely on an amino acid precursor as the chiral source, avoiding\nthe use of transition metals or additional organocatalysts. This reaction\nis efficient and scalable, enabling synthesis on a gram-scale.