Fluorinated Liquid-Crystal\nMonomers in Serum from\nthe General Population and Their Impact on Human Health

Fluorinated liquid-crystal monomers (FLCMs) are a potential\nemerging\nclass of persistent, bioaccumulative, and toxic compounds. Humans\ninevitably ingest FLCMs via food and the environment. However, there\nare limited studies on internal exposure biomonitoring of FLCMs. Herein,\nwe evaluated the estimated daily intakes (EDIs) of FLCMs in the general\npopulation based on serum residue levels. For the first time, 38 FLCMs\nwere detected in 314 serum samples from the general population in\nBeijing, with a median value of 132.48 ng/g of lipid weight (lw).\nBDPrB is a predominant FLCM in serum. The median EDI of ∑<sub>38</sub>FLCMs in the general residents was 37.96 pg/kg bw/day. The\nresidual levels of most FLCMs were higher in urban than in suburban\nareas (<i>p</i> < 0.05). The concentrations of EFPEB,\nEDPrB, EDFPBB, and PDTFMTFT in serum showed positive associations\nwith blood glucose (GLU) (<i>r</i> = 0.126–0.275, <i>p</i> < 0.05). Logistic regression analysis showed that FLCMs\nwere significantly positively correlated with dyslipidemia, with an\nodds ratio of 2.19; BDPrB was significantly positively correlated\nwith hyperglycemia (OR: 2.48). Overall, the present study suggests\nthe occurrence of FLCMs in the nonoccupational population, and the\nexposure of certain FLCMs may cause abnormal blood glucose and lipid\nlevels.