Unraveling\nCross-Organ\nImpacts of Airborne Pollutants: A Multiomics Study on Respiratory\nExposure and Gastrointestinal Health

Poor air quality is increasingly\nlinked to gastrointestinal\ndiseases, suggesting a potential correlation with human intestine\nhealth. However, this relationship remains largely unexplored due\nto limited research. This study used a controlled mouse model exposed\nto cooking oil fumes (COFs) and metagenomics, transcriptomics, and\nmetabolomics to elucidate interactions between intestine microbiota\nand host metabolism under environmental stress. Our findings reveal\nthat short-term COF inhalation induces pulmonary inflammation within\n3 days and leads to gastrointestinal disturbances, elucidating a pathway\nconnecting respiratory exposure to intestinal dysfunction. The exposure\nintensity significantly correlates with changes in intestinal tissue\nintegrity, microbial composition, and metabolic function. Extended\nexposure of 7 days disrupts intestine microbiota and alters tryptophan\nmetabolism, with further changes observed after 14 days, highlighting\nan adaptive response. These results highlight the vulnerability of\nintestinal health to airborne pollutants and suggest a pathway through\nwhich inhaled pollutants may affect distant organ systems.