Dual-Responsive\nAntibacterial Hydrogel Patch for Chronic-Infected\nWound Healing

Bacterial\ninfections in chronic wounds, such as bedsores and diabetic\nulcers, present significant healthcare challenges. Excessive antibiotic\nuse leads to drug resistance and lacks precision for targeted wound\ntreatment. Our study introduces an innovative solution: a near-infrared\n(NIR) and pH dual-responsive hydrogel patch incorporating regenerated\nsilk fibroin (RSF) and molybdenum dioxide (MoO<sub>2</sub>) nanoparticles\n(NPs), offering enhanced mechanical properties, precise drug release,\nand superior antibacterial efficacy. The dual-responsive hydrogel\npatch allows for precise control over antibiotic release triggered\nby NIR light and pH fluctuations, enabling tailored treatment for\ninfected wounds. First, the pH-responsive characteristic matches the\nalkaline environment of the infected wound, ensuring on-demand antibiotic\nrelease. Second, NIR exposure accelerates antibiotic release, enhancing\nwound healing and providing additional antibacterial effects. Additionally,\nthe patch further blocks bacterial infection, promotes wound repair,\nand degrades in sync with the healing process, further bolstering\nthe efficacy against wound infections.