Direct γ-C(sp3)–H Acylation of Amide Derivatives via Cooperative NHC and Photoredox Catalysis

Achieving the direct functionalization of chemically inert C(sp³)-H bonds under mild reaction conditions with organocatalysis continues to be a notable challenge in the field of synthetic chemistry. Herein, we report a remote C(sp³)-H acylation of amides via an NHC and photoredox dual-catalyzed mechanism involving a radical 1,5-hydrogen atom transfer (HAT). This method demonstrates a notable broad substrate scope, including amides derived from cyclopentyl, cyclohexyl, and extended alkyl chains, all of which furnished the corresponding products efficiently.