Single-cell transcriptomic profiling and machine learning identify S-nitrosylation-associated LAMC2 as a key prognostic driver in pancreatic cancer

This study establishes S-nitrosylation as a crucial PTM in pancreatic cancer and introduces a robust machine-learning-based prognostic model. LAMC2 is identified as a key oncogenic effector connecting S-nitrosylation dysregulation to tumor aggressiveness, providing novel prognostic and therapeutic insights for pancreatic cancer management.