Loss of GLP-2R signaling in Glp2r mice increases the long-term severity of graft versus host disease

Activation of GLP-2R signaling did not reduce the severity of experimental aGvHD, failing to replicate a previous study using an identical aGvHD protocol. Nevertheless, loss of GLP-2R signaling in transplant recipients decreased survival and increased bacteremia, implicating an essential role for endogenous GLP-2R signaling in maintaining barrier function in the context of immune-mediated gut epithelial injury.

Institutions

Publication Details

Journal
Molecular Metabolism
Published
2025-12-17
DOI
https://doi.org/10.1016/j.molmet.2025.102311
Primary Topic
Diabetes Treatment and Management
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Loss of GLP-2R signaling in Glp2r mice increases the long-term severity of graft versus host disease

Molecular Metabolism
Diabetes Treatment and Management
article

Loss of GLP-2R signaling in Glp2r mice increases the long-term severity of graft versus host disease

article en

Abstract

Activation of GLP-2R signaling did not reduce the severity of experimental aGvHD, failing to replicate a previous study using an identical aGvHD protocol. Nevertheless, loss of GLP-2R signaling in transplant recipients decreased survival and increased bacteremia, implicating an essential role for endogenous GLP-2R signaling in maintaining barrier function in the context of immune-mediated gut epithelial injury.

Molecular MetabolismVol. 103
Lunenfeld-Tanenbaum Research Institute (CA)
Openalex Percentile: Top 46%
Diabetes Treatment and Management
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Loss of GLP-2R signaling in Glp2r mice increases the long-term severity of graft versus host disease · Molecular Metabolism (2025) | TGRS Research Map | TGRS