Clinical impact of continuing osimertinib beyond progression versus best supportive care in EGFR-mutated advanced non-small cell lung cancer: a multi-institutional retrospective study

In real-world settings involving elderly and frail patients, osimertinib continuation beyond PD was associated with improved survival compared with BSC alone. Although chemotherapy remains the preferred strategy when feasible, osimertinib continuation beyond PD may represent a reasonable treatment option for patients who are ineligible for further cytotoxic therapy. In the absence of other guiding biomarkers, TTF may help clinicians identify patients most likely to benefit from continued TKI administration.