Type I and <scp>II</scp> Interferons Drive Abacavir Hypersensitivity via Treg Suppression and T‐Cell Enhancement in Immunocompetent <scp>HLA</scp> ‐Transgenic Mice
In vivo upregulation of HLA expression modulates the balance between drug-specific and regulatory T cells, thereby promoting optimal pDC expansion and enhancing IFN-α production, which counteracts Treg-mediated ABC tolerance. IFN-γ secretion by drug-specific CD8<sup>+</sup> T-cells promoted APC and effector T-cell function that led to the development of ABC-associated hypersensitivity reactions in immunocompetent HLA Tg mice.
Institutions
- Center for Biologics Evaluation and Research (US)
- Center for Drug Evaluation and Research (US)
Publication Details
- Journal
- Allergy
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1111/all.70189
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Energy
- U.S. Food and Drug Administration
- Oak Ridge Institute for Science and Education