A multi-layered regulatory model uncovers the central role of OsPRR37 in coordinating multiple agronomic traits

The findings establish OsPRR37 as a central regulatory hub that coordinates flowering, energy metabolism, chloroplast function, and stress adaptation through a hierarchical network comprising a Modulatory Layer of protein interactors, a Direct Target Layer of DNA-bound genes, an Indirect Coherent Layer of transcriptional cascades, and a Diffuse Response Layer encompassing broad metabolic outputs. This model provides a comprehensive framework for understanding how OsPRR37 integrates circadian signals to control multiple agronomic traits and offers valuable targets for breeding climate-resilient, high-yielding rice varieties.