Keeping a stiff upper lip: p120ctn and tissue fusion

In this issue, Teng et al. (https://doi.org/10.1083/jcb.202503070) use genome editing, classical tissue-specific gene knockouts, and live cell imaging to show that the interaction of p120ctn with the juxtamembrane domain of classical cadherins is necessary for tissue integrity during the cellular zippering required for upper lip formation in mammals.

Institutions

University of Wisconsin–Madison (US)

Publication Details

Journal: The Journal of Cell Biology
Published: 2025-12-05
DOI: https://doi.org/10.1083/jcb.202511015
Primary Topic: Wnt/β-catenin signaling in development and cancer
Type: article
Field-Weighted Citation Impact: 0.00

Funders

National Institutes of Health

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article

Keeping a stiff upper lip: p120ctn and tissue fusion

Dec 5, 2025

The Journal of Cell Biology

Wnt/β-catenin signaling in development and cancer

article

Keeping a stiff upper lip: p120ctn and tissue fusion

December 5, 2025article en

Abstract

The Journal of Cell BiologyVol. 225(1)

University of Wisconsin–Madison (US)

National Institutes of Health

Openalex Percentile: Top 62%

Wnt/β-catenin signaling in development and cancer

DOI Open Access PDF OpenAlex

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