Effect of free fatty acids on TGF-β1 mediated fibrogenesis in hepatic stellate cells

These results suggest that in activated HSCs, palmitate oxidation is reduced and that TCA cycle intermediates derived from palmitate are used as carbon sources for amino acid production that supports collagen synthesis and secretion.

Institutions

Publication Details

Journal
Molecular Metabolism
Published
2025-12-17
DOI
https://doi.org/10.1016/j.molmet.2025.102309
Citations
2
Primary Topic
Liver physiology and pathology
Type
article
Field-Weighted Citation Impact
2.64
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article

Effect of free fatty acids on TGF-β1 mediated fibrogenesis in hepatic stellate cells

2 citations
Molecular Metabolism
Liver physiology and pathology
2.64
article

Effect of free fatty acids on TGF-β1 mediated fibrogenesis in hepatic stellate cells

article en
2 citations

Abstract

These results suggest that in activated HSCs, palmitate oxidation is reduced and that TCA cycle intermediates derived from palmitate are used as carbon sources for amino acid production that supports collagen synthesis and secretion.

Molecular MetabolismVol. 104
The University of Melbourne (AU), Gilead Sciences (United States) (US), Melbourne Genomics Health Alliance (AU), RMIT University (AU)
Openalex Percentile: Top 8%
Liver physiology and pathology
2.64
DOIOpen Access PDFOpenAlex
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Effect of free fatty acids on TGF-β1 mediated fibrogenesis in hepatic stellate cells · Molecular Metabolism (2025) | TGRS Research Map | TGRS