Development and validation of a novel glioblastoma prognostic model: identifying STOX1 and ZNF248 as ferroptosis-related biomarkers
We present a validated 14-gene prognostic model that accurately predicts GBM patient outcomes and reveals STOX1 and ZNF248 as novel tumor suppressors related to ferroptosis. Targeting STOX1 and ZNF248 may overcome the resistance of GBM to ferroptosis and improve therapeutic efficacy.
Institutions
- University of Science and Technology of China (CN)
- Chinese University of Hong Kong (HK)
- Chinese Academy of Sciences (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- Shenzhen University Health Science Center (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-12-21
- DOI
- https://doi.org/10.1186/s12935-025-04126-w
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00