Prevalence Of Different Clinical Phenotypes Of PCOS And Their Response To Ovulation Induction

Introductions: The NIH 2012 evidence-based approach workshop on PCOS identified four main phenotypes. Symptoms include polycystic ovarian morphology (PCOM), ovulatory dysfunction, and excess androgen in phenotypes A, B, C, and D. Aim of the study: This research aims to assess the prevalence of various PCOS clinical phenotypes and how they react to ovulation induction.Subjects and Methods: An infertile woman visiting Fayoum University Hospitals' Infertility Clinic participated in this cross-sectional research. Infertility was used to split individuals in this randomized experiment. Each arm included 200 19–37-year-old infertile women. Results: A and C were the most common in this cross-sectional (50 and 29%), whereas B and D were just 7% and 19%. A had higher primary infertility, whereas B and D had higher secondary. The levels of FSH, Prolactin, cortisol, and free testosterone were similar amongst PCO types. Type D exhibited a significant drop in 17 α-OHP compared to other types. Total testosterone was higher in Type A. Type A had more right-sided antral follicles than others. Types A and D have far more left-sided antral follicles. Compared to others. PCO types reacted differentially to Clomiphene. A was more clomiphene-resistant than others, although C was more sensitive.Conclusion: The research found phenotypic group A dominates PCOS. Phenotypic type A has higher metabolic and cardiovascular difficulties than other groups due to insulin resistance, hyperandrogenism, obesity, disordered metabolic syndrome, and lipid profile. This group is also more clomiphene-resistant. Phenotype D is the mildest PCOS. Acne; Biotinidase; Depression; Isotretinoin.