Serum Endogline In Preeclamptic Patients

Background: Pre-eclampsia (PE) is a multisystem disorder that is specific to pregnancy, characterized by progressing proteinuria and hypertension after twenty weeks of gestation.Aim: This research aimed to define endoglin levels in the serum of preeclamptic patients and compare these levels to non-PE patients.Patients and methods: The case-control research was performed on forty cases diagnosed with PE, who have new-onset hypertension, and 40 healthy pregnant controls and gestational ages ranged from 28 to 40 weeks. Cases were categorized into three groups: Group A (40 cases), the control group; Group B (20 cases), diagnosed with mild PE; Group C (20 cases), diagnosed with severe PE. ELISA measured serum endoglin for all three groups.Results: There was significant variance among studied groups, according to endoglin, as it was significantly higher in severe preeclamptic patients. It could discriminate between mild PE and control group at cutoff 5.33 with sensitivity 85%, specificity 42.5%, PPV 59.4% and NPV 73.7% and between severe PE and control group at cutoff 5.21 with sensitivity85%, specificity 75%, PPV 77% and NPV 83% and between mild PE and severe PE at cutoff 5.61 with sensitivity90%, specificity 65%, PPV 72% and NPV 87%.Conclusions: serum endoglin proved to be of value in case of PE as it shows significant increase in severe PE.