Carbetocin, Misoprostol and Oxytocin Uses in Prophylaxis of Postpartum Hemorrhage in High-Risk Patients: Prospective Hospital-Based Study

Background: Postpartum haemorrhage (PPH) is severe bleeding following giving birth. It is a serious and risky condition.Aim: To compare misoprostol, Carbetocin, and Oxytocin for prophylaxis of postpartum bleeding in the high-risk cases of CS.Patients and methods: This prospective comparative research was done on cases admitted to the Obstetrics & Gynecology department at Al-Azhar University hospitals of Assuit and Luxor International Hospital in the period from 2022 to 2024.Results: There significant variances were observed among groups in terms of procedures, for example, ergometrine, uterine artery ligation, compression sutures, hysterectomy, and blood transfusion. Post-operatively p<0.05, their insignificant variations were observed in haemoglobin (g/dl) or hematocrit value among groups p>0.05. Also, there significant variances were observed among groups in terms of abdominal pain, heat sensation, shivering, metallic taste, fever, headache, palpitations, nausea, vomiting, pruri p<0.05, but insignificant variance was discovered in headache, nausea, vomiting, and pruri p>0.05.Conclusion: Carbetocin is a more effective treatment for preventing atonic postpartum haemorrhage in caesarean delivery patients who have high-risk characteristics. It requires fewer uterotonic medicines or surgical hemostatic measures in comparison to Oxytocin and misoprostol. Additionally, Carbetocin produces sustained uterine tetanic spasm throughout and following delivery.