Therapeutic Effects of MyoInositol Versus Metformin Regarding Menstrual Irregularities and Infertility in Patients with Polycystic Ovarian Syndrome in Port said University Hospital

Background: Polycystic ovarian syndrome (PCOS) is hormonal disorder in women of reproductive age causing irregular periods, infertility, and metabolic issues. It is linked to insulin resistance and high androgen levels. Metformin and Myoinositol are treatments that improve menstrual regularity and fertility in PCOS. This study aimed to compare their effectiveness in managing menstrual irregularities and infertility and the reduction of PCO related menstrual irregularities and infertility among females aged (18-35).Methods: This prospective randomized controlled study was carried out on 48 females aged between 18 and 35 years, diagnosed with PCOS in terms of the Rotterdam consensus, complaining of both infertility and menstrual irregularities (phenotype D), BMI (18-29 kg/m2).Patients were randomly divided into two groups: group A: received Myoinositol 1 gm once daily and group B received Metformin 2000 mg per day.Results: there was statistical significance between two drugs regarding BMI post 6 months use (P< 0.05), there were a statistically significant relation with any parameter with the selected drug. There was a statistically significance relation between the compliance to treatment & the type of drug given but otherwise, there were no statistically significant relation with any parameter with the selected drug. Conclusions: Both myoinositol and metformin effective for PCOS, especially for menstrual issues and infertility. Myoinositol led to better ovulation and pregnancy rates with fewer side effects, while metformin was more effective for reducing BMI but had lower tolerability. Myoinositol is a safer, more tolerable option for improving fertility, while metformin may suit those needing metabolic control.