From Collagen Stimulation to Skin Regeneration: The Action of Fractional CO2 Laser and Insulin in atrophic acne scars

Background: Post-acne scars, which typically do not go away with time, are a persistent and frequently upsetting consequence of acne. These scars can become more noticeable as the skin ages. Acne scars develop from inflammatory acne lesions, and their severity is closely related to the intensity of the acne lesions, their duration, and the time of medical treatment. Understanding these factors is essential for effective scar management and prevention. Fractional CO₂ laser therapy has shown greater effectiveness compared to other laser treatments. It can also be used for laser-assisted drug delivery, allowing topical drugs such as growth hormones to penetrate more effectively. Insulin is a peptide hormone that acts as a growth factor during wound healing and skin regeneration. Objective: This review article aimed to describe the action of the fractional CO2 laser with multiple combinations. Various methods of applying insulin also play a significant role in treating atrophic acne scars. Conclusion: Multiple therapeutic modalities are required for effective management of atrophic post-acne scars. Fractional CO₂ laser and insulin in combination with other therapeutic options are effective, safe, and well-tolerated.