Assessment of serum minerals levels and thyroid hormones in Hypothyroidism patients in Baghdad-Iraq

Hypothyroidism is the most prevalent type of hormonal dysfunction. The prevalence of hypothyroidism has grown since 2003 among Iraqis. Thyroid hormones are essential for the homeostasis of mineral metabolism, body&#039;s hemodynamics, and metabolism. Hence, diseases related to thyroid perhaps impact glomerular filtration, renal hemodynamics, and mineral organization. Objective: to appraise the alteration of (calcium, magnesium and phosphorous) levels and investigating their correlation with thyroid profile in hypothyroidism individuals compared to healthy group. Methods: A case-control study was achieved, 70 patients with hypothyroid and 70 healthy as controls were included (age group 22-60 years). TSH,T3 and T4 levels of subjects were assessed by an automated quantitative analyzer (Cobas-e411). Calcium, magnesium and phosphorous levels of subjects were estimated by full-automatic-analyzer Spinreact. Results: Serum calcium levels showed a significant decrease (p<0.001), whereas a significant rise in serum magnesium and phosphorous levels (p<0.001) was found in patients compared to controls. A significant negative correlation (p<0.001) was found among patients between TSH and calcium, T3 and magnesium, T3 and phosphorus, T4 and magnesium, T4 and phosphorus, whereas positive correlation (p<0.001) was observed between T3 and calcium, T4 and calcium, TSH and magnesium, TSH and phosphorus. Conclusion: The research showed a significant influence of thyroid hormones on these minerals. Patients with hypothyroidism should have routine evaluations for calcium, magnesium and phosphorus levels since failing to regulate these levels early on might lead to more serious problems from impaired mineral metabolism.