Ellagic Acid Ameliorates Diabetic Cardiomyopathy by Inhibiting Ferroptosis Through the Modulation of the SIRT1/p53 Pathway in Streptozotocin-Induced Diabetic Rats
The EA mitigates DCM by suppressing ferroptosis, potentially through modulation of the SIRT1/p53 pathway, thereby improving cardiac function and metabolic homeostasis. However, as this study utilized an STZ-induced model of type 1 diabetes, further research is warranted to confirm its efficacy in type 2 diabetic contexts.
Institutions
- Shandong Provincial Hospital (CN)
- Shaanxi Provincial Hospital of Traditional Chinese Medicine (CN)
- Chinese Journal of Integrated Traditional and Western Medicine (CN)
Publication Details
- Journal
- Iranian journal of pharmaceutical research
- Published
- 2025-12-02
- DOI
- https://doi.org/10.5812/ijpr-166600
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00