Ketone bodies for hemodynamic support in acute pulmonary embolism: a randomized, blinded, controlled animal study
3-OHB reduced PVR/SVR ratio, while CO was not significantly increased in a porcine model of acute PE. The present findings demonstrated potential hemodynamic effects in PE. Further studies are needed to explore the translational potential of ketone body therapy in humans with PE.
Authors
- Simone Juel Dragsbæk (ORCID: https://orcid.org/0000-0001-9021-8975)
- Anders Kramer (ORCID: https://orcid.org/0000-0002-5546-8693)
- Kristoffer Berg‐Hansen (ORCID: https://orcid.org/0000-0002-5110-0656)
- Ebbe Boedtkjer (ORCID: https://orcid.org/0000-0002-5078-9279)
- Jacob Valentin Hansen (ORCID: https://orcid.org/0000-0002-7017-575X)
- Nigopan Gopalasingam (ORCID: https://orcid.org/0009-0006-6363-7406)
- Jacob Seefeldt (ORCID: https://orcid.org/0000-0002-0633-5878)
- Mads Dam Lyhne (ORCID: https://orcid.org/0000-0001-5279-260X)
- Alf Inge Larsen (ORCID: https://orcid.org/0000-0002-9141-0499)
- Roni Nielsen (ORCID: https://orcid.org/0000-0001-9228-3869)
- Ann Overgaard
- Louisa Christensen (ORCID: https://orcid.org/0000-0003-1448-5646)
- Casper Homilius (ORCID: https://orcid.org/0000-0002-8618-8109)
- Oskar Kjærgaard Hørsdal (ORCID: https://orcid.org/0000-0003-1009-3768)
- Asger Andersen (ORCID: https://orcid.org/0000-0002-0121-345X)
- Mark Stoltenberg Ellegaard (ORCID: https://orcid.org/0009-0000-9279-6269)
Institutions
- Aarhus University (DK)
- Aarhus University Hospital (DK)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1186/s40635-025-00844-7
- Primary Topic
- Renal function and acid-base balance
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hjerteforeningen
- Novo Nordisk
- Novo Nordisk Fonden
- Oda og Hans Svenningsens Fond
- National Institutes of Health