Elevated FGF23 Despite Biochemical Control Reveals Hidden Mineral Dysregulation in Chronic Hypoparathyroidism
FGF23 is frequently elevated in chronic hypoparathyroidism, indicating a disrupted phosphate metabolism, and its increase seems to be ineffective in promoting phosphate excretion, probably due to renal resistance mechanisms. Further studies are needed to clarify the role of FGF23 as a clinical biomarker, risk factor, and potential therapeutic target in this population.
Authors
- Cristiano Cantone
- Nicolò Bisceglia (ORCID: https://orcid.org/0009-0004-3202-3300)
- Matteo Malagrinò (ORCID: https://orcid.org/0000-0001-8157-6279)
- Sandra Capra (ORCID: https://orcid.org/0000-0002-0926-8500)
- Uberto Pagotto (ORCID: https://orcid.org/0000-0003-4182-3110)
- Guido Zavatta (ORCID: https://orcid.org/0000-0003-3657-2070)
- Anna Piazza (ORCID: https://orcid.org/0000-0002-9785-3397)
Institutions
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Azienda USL di Bologna (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Journal of the Endocrine Society
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1210/jendso/bvaf217
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00