An Unusual Case of an Extra-salivary Subcutaneous Multifocal Pleomorphic Salivary Adenoma

A 36-year-old woman was referred to the Oral and Maxillofacial Surgery clinic at Pinderfields Hospital, Wakefield, with multiple subcutaneous swellings on the right side of the face, overlying the parotid region and extending below the mandibular border. Magnetic resonance imaging (MRI) revealed several macrocystic subcutaneous lesions, and ultrasound-guided fine-needle aspiration confirmed a diagnosis of pleomorphic salivary adenoma (PSA). The lesions were excised via a modified Blair incision and were found to be superficial to the parotid capsule. Histopathological evaluation showed myxoid-rich PSAs without any associated salivary gland tissue, confirming an extrasalivary origin. This case illustrates a rare presentation of multifocal, subcutaneous PSAs occurring independently of the parotid gland. The patient remains disease-free and continues under routine surveillance for potential recurrence.

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Publication Details

Journal
Cureus
Published
2025-12-20
DOI
https://doi.org/10.7759/cureus.99723
Primary Topic
Salivary Gland Tumors Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

An Unusual Case of an Extra-salivary Subcutaneous Multifocal Pleomorphic Salivary Adenoma

Mohammed Anabtawi, Gordon Hutchins, Conor Gordon, Shailendra Walunj
Cureus
Salivary Gland Tumors Diagnosis and Treatment
article

An Unusual Case of an Extra-salivary Subcutaneous Multifocal Pleomorphic Salivary Adenoma

Mohammed Anabtawi, Gordon Hutchins, Conor Gordon, Shailendra Walunj
article en

Abstract

A 36-year-old woman was referred to the Oral and Maxillofacial Surgery clinic at Pinderfields Hospital, Wakefield, with multiple subcutaneous swellings on the right side of the face, overlying the parotid region and extending below the mandibular border. Magnetic resonance imaging (MRI) revealed several macrocystic subcutaneous lesions, and ultrasound-guided fine-needle aspiration confirmed a diagnosis of pleomorphic salivary adenoma (PSA). The lesions were excised via a modified Blair incision and were found to be superficial to the parotid capsule. Histopathological evaluation showed myxoid-rich PSAs without any associated salivary gland tissue, confirming an extrasalivary origin. This case illustrates a rare presentation of multifocal, subcutaneous PSAs occurring independently of the parotid gland. The patient remains disease-free and continues under routine surveillance for potential recurrence.

CureusVol. 17(12)
Leeds General Infirmary (GB), Pinderfields Hospital (GB)
Openalex Percentile: Top 39%
Salivary Gland Tumors Diagnosis and Treatment
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An Unusual Case of an Extra-salivary Subcutaneous Multifocal Pleomorphic Salivary Adenoma — Mohammed Anabtawi, Gordon Hutchins, et al. · Cureus (2025) | TGRS Research Map | TGRS