Combined action of suicide gene exosomes from pancreatic cancer-associated fibroblasts and from mesenchymal stem cells as a pancreatic ductal adenocarcinoma treatment approach
Exosomes containing the yCD::UPRT gene from pCAFs and MSCs function as "Trojan horse" therapies, efficiently and dose-dependently eliminating pancreatic cancer cells. PDAC environment-targeted yCD::UPRT-gene exosomes from MSCs and pCAFs show promise for a novel PDAC treatment.
Authors
- Ursula Altanerova (ORCID: https://orcid.org/0009-0005-9663-0772)
- Peter J. Makovicky (ORCID: https://orcid.org/0000-0001-9307-9982)
- Zbyněk Zdráhal (ORCID: https://orcid.org/0000-0003-3044-5548)
- Č Altaner (ORCID: https://orcid.org/0000-0001-6998-0885)
- Jana Jakubechova (ORCID: https://orcid.org/0009-0007-6326-5929)
- Maria Urbanova (ORCID: https://orcid.org/0000-0003-0931-0032)
- Verona Buociková (ORCID: https://orcid.org/0000-0002-2466-9126)
- Georgina Kolníková
- Tatiana Zeleznikova
- Monika Buríková (ORCID: https://orcid.org/0000-0002-4697-6389)
- Peter Dubovan (ORCID: https://orcid.org/0000-0002-0853-4045)
- Božena Smolková (ORCID: https://orcid.org/0000-0002-4906-5652)
- David Potěšil (ORCID: https://orcid.org/0000-0003-0390-0904)
- Marina Cihova (ORCID: https://orcid.org/0000-0001-9205-4214)
- Kristína Jakič (ORCID: https://orcid.org/0000-0002-8251-5328)
- Miroslav Tomáš (ORCID: https://orcid.org/0000-0002-1114-5120)
- Dajana Vanova (ORCID: https://orcid.org/0009-0002-1237-3536)
- Michal Andrezal (ORCID: https://orcid.org/0009-0005-5056-1556)
- Václav Pustka (ORCID: https://orcid.org/0009-0005-9857-3601)
- Benjamin Spanik
- Veronika Repaska
- Peter Bartek
Institutions
- Central European Institute of Technology (CZ)
- Central European Institute of Technology – Masaryk University (CZ)
- National Institute of Cardiovascular Diseases (SK)
- Cancer Research Institute of the Slovak Academy of Sciences (SK)
- Biomedical Research Center of the Slovak Academy of Sciences (SK)
- National Cancer Institute (MY)
- Comenius University Bratislava (SK)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-12-20
- DOI
- https://doi.org/10.1186/s12935-025-04130-0
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00