A prospective investigation of early-onset colorectal cancer risk factors–pooled analysis of three large-scale European cohorts
Adiposity, physical inactivity, smoking, and alcohol consumption are risk factors for EOCRC. Risk factors were largely similar between EOCRC and LOCRC, except for adiposity, with stronger EOCRC association in men.
Authors
- Valeria Pala (ORCID: https://orcid.org/0000-0001-5438-970X)
- Paul Brennan (ORCID: https://orcid.org/0000-0003-1128-6254)
- Guri Skeie (ORCID: https://orcid.org/0000-0003-2476-4251)
- Ruhina Shirin Laskar (ORCID: https://orcid.org/0000-0001-6455-094X)
- Amanda J. Cross (ORCID: https://orcid.org/0000-0001-6001-9211)
- Karl Smith-Byrne (ORCID: https://orcid.org/0000-0002-1932-7463)
- Pietro Ferrari (ORCID: https://orcid.org/0000-0001-9358-7338)
- Renée T. Fortner (ORCID: https://orcid.org/0000-0002-1426-8505)
- Neil Murphy (ORCID: https://orcid.org/0000-0003-3347-8249)
- Therese Haugdahl Nøst (ORCID: https://orcid.org/0000-0001-6805-3094)
- Marcela Guevara (ORCID: https://orcid.org/0000-0001-9242-6364)
- Kristin Benjaminsen Borch (ORCID: https://orcid.org/0000-0002-1741-2322)
- Marc J. Gunter (ORCID: https://orcid.org/0000-0001-5472-6761)
- Tonje Braaten (ORCID: https://orcid.org/0000-0003-4394-6149)
- Anne Marie Tjønneland (ORCID: https://orcid.org/0000-0003-4385-2097)
- Peter T. Campbell
Institutions
- University of Copenhagen (DK)
- Albert Einstein College of Medicine (US)
- Norwegian Institute of Public Health (NO)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University of Cambridge (GB)
- University of Oxford (GB)
- Instituto de Salud Pública de Navarra (ES)
- Navarre Institute of Health Research (ES)
- Cancer Registry of Norway (NO)
- Danish Cancer Society (DK)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Centre international de recherche sur le cancer (FR)
- Imperial College London (GB)
- UiT The Arctic University of Norway (NO)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2025-12-20
- DOI
- https://doi.org/10.1038/s41416-025-03303-y
- Citations
- 2
- Primary Topic
- Colorectal Cancer Screening and Detection
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- World Cancer Research Fund International
- Institut National Du Cancer
- World Cancer Research Fund
- National Cancer Institute