Resveratrol synergizes with cisplatin to suppress osteosarcoma U2-OS cells via up-regulating Cx43 and inducing ROS-dependent apoptosis
Res combined with CDDP exerts a synergistic inhibitory effect on osteosarcoma by upregulating Cx43 and inducing ROS-dependent apoptosis. This study may provide a novel therapeutic strategy and potential clinical applications for osteosarcoma treatment.
Authors
- Lei Zhai (ORCID: https://orcid.org/0000-0003-2106-5981)
- Xiang Wu (ORCID: https://orcid.org/0000-0002-2134-1184)
- Qihao Zhang (ORCID: https://orcid.org/0009-0003-2057-3316)
- Hao Xing (ORCID: https://orcid.org/0000-0002-9325-3466)
- Guizhou Zheng
- Haoyu Li (ORCID: https://orcid.org/0000-0003-2687-5289)
- Xuedong Li (ORCID: https://orcid.org/0009-0005-0467-8526)
- Shi‐xin Du
Institutions
- Anhui University of Science and Technology (CN)
- Shenzhen Luohu People's Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-12-20
- DOI
- https://doi.org/10.1007/s12672-025-04313-1
- Citations
- 1
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 1.22