Development of the first prediction model for radiation-induced contrast enhancement after proton therapy for posterior fossa tumours in paediatric patients
We developed models to predict RICE in paediatric patients. The RICE probability at the voxel- and patient-level increased with D and D⋅LETd, younger age and within the brainstem pons.
Authors
- Johannes A. Langendijk (ORCID: https://orcid.org/0000-0003-1083-372X)
- Abel Bregman (ORCID: https://orcid.org/0009-0001-7481-1733)
- Truls Andersen (ORCID: https://orcid.org/0000-0001-6260-9661)
- John H. Maduro (ORCID: https://orcid.org/0000-0003-2458-8702)
- Stefan Both (ORCID: https://orcid.org/0000-0001-6652-6054)
- A. van der Schaaf (ORCID: https://orcid.org/0000-0003-4067-7975)
- Charlotte L. Brouwer (ORCID: https://orcid.org/0000-0002-2349-7369)
- Rutger A. J. Nievelstein (ORCID: https://orcid.org/0000-0002-0484-1486)
- Hiska L. van der Weide (ORCID: https://orcid.org/0000-0001-6734-2345)
- Eelco W. Hoving (ORCID: https://orcid.org/0000-0002-5587-0439)
- Maarten H. Lequin (ORCID: https://orcid.org/0000-0001-7488-1734)
- Geert O. Janssens (ORCID: https://orcid.org/0000-0002-0331-713X)
- Jikke J. Rutgers (ORCID: https://orcid.org/0000-0003-3727-5326)
- Dirk Wagenaar (ORCID: https://orcid.org/0000-0001-8321-6824)
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- University Medical Center Utrecht (NL)
- Princess Máxima Center (NL)
- Wilhelmina Children's Hospital (NL)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2025-12-20
- DOI
- https://doi.org/10.1016/j.radonc.2025.111360
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 0.00