Insilico analysis of the pathogenic deletion mutations (CFTR-F508del) associated with cystic fibrosis disease
The integration of genetic, structural, and docking analyses supports the role of Ivacaftor as an effective modulator of F508del-CFTR function. The identified interaction hotspots offer a structural basis for optimizing CFTR-targeted therapeutics and support further exploration of personalized drug design in CF treatment.
Authors
- Maryam Dhary Kamel (ORCID: https://orcid.org/0000-0001-9292-2632)
Institutions
- University of Technology - Iraq (IQ)
Publication Details
- Journal
- Computational Biology and Chemistry
- Published
- 2025-12-20
- DOI
- https://doi.org/10.1016/j.compbiolchem.2025.108865
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00