Elevated SARS-CoV-2 IgG4 in plasma and mucosa following repeated mRNA boosters impact antibody functions to Omicron and sarbecoviruses
This study was supported by the VC2 Research Fund and an NHMRC Investigator grant #2008092. Sample collection was supported by WHO Unity funds (2020/1085469-0) and WEHI Philanthropic Funds.
Authors
- Adam K. Wheatley (ORCID: https://orcid.org/0000-0002-5593-9387)
- Laura Elizabeth Downie (ORCID: https://orcid.org/0000-0002-1596-2259)
- Wai‐Hong Tham (ORCID: https://orcid.org/0000-0001-7950-8699)
- Nicholas Kiernan‐Walker (ORCID: https://orcid.org/0009-0006-0014-2561)
- Kevin J. Selva (ORCID: https://orcid.org/0000-0002-0780-9422)
- Janine M. Trevillyan (ORCID: https://orcid.org/0000-0002-8660-5558)
- Jennifer A. Juno (ORCID: https://orcid.org/0000-0002-9072-1017)
- Stephen John Kent (ORCID: https://orcid.org/0000-0002-8539-4891)
- Jennifer Audsley (ORCID: https://orcid.org/0000-0001-6322-3197)
- Helen E. Kent
- Wen Shi Lee (ORCID: https://orcid.org/0000-0001-7285-4054)
- Emily M. Eriksson (ORCID: https://orcid.org/0000-0002-7851-973X)
- Phillip Pymm (ORCID: https://orcid.org/0000-0003-2722-4621)
- Amy W. Chung (ORCID: https://orcid.org/0000-0003-0020-9704)
- L. Carissa Aurelia
- A. Enríquez (ORCID: https://orcid.org/0000-0003-3649-632X)
- J. Judy Chang
Institutions
- Australian National University (AU)
- The Royal Melbourne Hospital (AU)
- The University of Melbourne (AU)
- Walter and Eliza Hall Institute of Medical Research (AU)
- Australian College of Optometry (AU)
- Melbourne Sexual Health Centre (AU)
- Peter Doherty Institute (AU)
Publication Details
- Journal
- EBioMedicine
- Published
- 2025-12-20
- DOI
- https://doi.org/10.1016/j.ebiom.2025.106087
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00