Comparative Effectiveness of Long Acting Injectable Versus Oral Naltrexone in Patients with Co-Occurring Posttraumatic Stress Disorder and Alcohol Use Disorder
Our analyses suggest that LAI naltrexone provides no benefits in improving PTSD or AUD outcomes compared to its oral counterpart among patients with comorbid PTSD and AUD. In fact, our results suggest that oral naltrexone may provide an increased probability of clinically meaning PTSD improvements if a high level of medication adherence is maintained.
Authors
- Jiang Gui (ORCID: https://orcid.org/0000-0001-5377-8914)
- Eleanor J. Murray (ORCID: https://orcid.org/0000-0003-0043-4901)
- Jaimie L. Gradus (ORCID: https://orcid.org/0000-0003-1459-5327)
- Luke Rozema (ORCID: https://orcid.org/0000-0003-3438-5343)
- Brian Shiner (ORCID: https://orcid.org/0000-0003-1623-8841)
- Bradley V. Watts (ORCID: https://orcid.org/0000-0003-2397-6359)
Institutions
- Dartmouth College (US)
- Boston University (US)
- Veterans Health Administration (US)
- White River Junction VA Medical Center (US)
- National Center for Post Traumatic Stress Disorder (US)
Publication Details
- Journal
- Journal of Dual Diagnosis
- Published
- 2025-12-20
- DOI
- https://doi.org/10.1080/15504263.2025.2603711
- Primary Topic
- Substance Abuse Treatment and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00