Viral diversity influences T-cell responses to enteric human adenoviruses F40 and F41
The hexon and penton proteins of HAdV-F-40 and F41 are predicted to contain a number of genotype-specific, but conserved, Class I epitopes which could be used to inform future vaccine design. Using the hexon of F41 as a case study, we show that predicted T-cell epitopes in emergent strains are able to elicit an inflammatory cytokine response from healthy donor PBMC. The role of T-cell recognition in driving enteric adenovirus evolution deserves further consideration.
Authors
- Charlotte J. Houldcroft (ORCID: https://orcid.org/0000-0002-1833-5285)
- Charles N. Agoti (ORCID: https://orcid.org/0000-0002-2160-567X)
- Arnold W. Lambisia (ORCID: https://orcid.org/0000-0001-5312-0960)
- Benjamin A. Krishna (ORCID: https://orcid.org/0000-0003-0919-2961)
- Benjamin J. Ravenhill
- Holly M. Craven (ORCID: https://orcid.org/0000-0001-5344-7058)
- Jennifer P. Hoang
- Rookmini Mukhopadhyay
Institutions
- University of Cambridge (GB)
- Kenya Medical Research Institute (KE)
- Cambridge School (PT)
- Bridge University (SS)
Publication Details
- Journal
- Virus Evolution
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1093/ve/veaf098
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00