Cytotoxic Effects of Mono- and Trinuclear Platinum(II)–N-Heterocyclic Carbene Complexes against Triple-Negative Breast Cancer Cell Lines
Platinum(II) complexes with N-heterocyclic carbene (NHC) ligands have been demonstrated as intriguing and promising foundations to construct novel metal-based anticancer drugs. To the best of our knowledge, there is no report of trinuclear Pt<sup>II</sup>-NHC complexes showcasing cytotoxicity toward cancer cells. Herein, we introduce the synthesis and characterization of the first examples of trinuclear platinum(II) complexes possessing a tris-NHC ligand, along with the corresponding mononuclear complexes. The <i>in vitro</i> cytotoxicity assessment of these complexes is explored against three breast cancer cell lines, 4T1, MDA-MB-231, and MCF-7, and a liver cancer cell line, Hep G2, and the results are compared with values obtained for the standard platinum drug cisplatin.
Authors
- Ugir Hossain Sk (ORCID: https://orcid.org/0000-0001-7393-454X)
- Ramananda Maity (ORCID: https://orcid.org/0000-0002-2815-8905)
- Tasnim Ria
- Asim Halder (ORCID: https://orcid.org/0000-0002-4120-788X)
- Bhaskar Mondal (ORCID: https://orcid.org/0000-0001-6660-3320)
- Soumitra Chowdhury (ORCID: https://orcid.org/0000-0003-4301-478X)
Institutions
- University of Calcutta (IN)
- Chittaranjan National Cancer Institute (IN)
Publication Details
- Journal
- Inorganic Chemistry
- Published
- 2025-12-20
- DOI
- https://doi.org/10.1021/acs.inorgchem.5c03954
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 0.00