Roseburia intestinalis-derived inosine improves intestinal motility by activating TGF-β1/p-Smad3/Transgelin signaling axis
These findings established that RI and its metabolite inosine promote intestinal motility via TGF-β1/p-Smad3 signaling and identified transgelin as the terminal effector of this cascade, offering mechanistic insight into microbiota-host interactions and pointing to therapeutic targets for gastrointestinal motility disorders.
Authors
- Hao Zhang (ORCID: https://orcid.org/0000-0003-4732-8049)
- Mengshi Chen
- Hao Ruan (ORCID: https://orcid.org/0000-0001-6293-2485)
- Weilong Zhong (ORCID: https://orcid.org/0000-0002-7139-169X)
- Bangmao Wang (ORCID: https://orcid.org/0000-0003-2796-1584)
- Kui Jiang (ORCID: https://orcid.org/0000-0001-7097-7771)
- Haifeng Liu (ORCID: https://orcid.org/0000-0002-0912-913X)
- Ming Sun
- Xiaoqian Dong
Institutions
- Fujian Medical University (CN)
- Nankai University (CN)
- Tianjin Medical University General Hospital (CN)
- China Resources (China) (CN)
- Office of the Chief Scientist (IL)
- Tianjin Infectious Diseases Hospital (CN)
- Fujian Provincial Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-20
- DOI
- https://doi.org/10.1186/s12967-025-07366-6
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00