Immunomodulatory Mechanisms of Rehmanniae Radix Praeparata–Achyranthes Root–Chinese Angelica Root Combination in Nontraumatic Osteonecrosis of the Femoral Head: A Comprehensive Network Pharmacology and Molecular Docking Study Focusing on Immunologica
Our integrated analysis suggests that SND alleviates NONFH primarily through multi-target immunomodulation, explicitly involving suppression of NET formation and regulation of immune cell activity, especially neutrophils and osteoclasts. This study presents a novel, immunologically explicit hypothesis for the mechanism of SND against NONFH, providing a solid theoretical foundation for future experimental validation and clinical application.
Authors
- Wei Huang (ORCID: https://orcid.org/0000-0001-9116-2985)
- Yusong Liu (ORCID: https://orcid.org/0009-0009-6769-3802)
- Caiying Liu (ORCID: https://orcid.org/0009-0002-4576-8753)
- Leilei Qin (ORCID: https://orcid.org/0000-0002-9443-7080)
- Chaozong Liu (ORCID: https://orcid.org/0000-0002-9854-4043)
- Liqi Ng (ORCID: https://orcid.org/0000-0002-7049-0012)
- Pengcheng Xiao (ORCID: https://orcid.org/0000-0002-0266-392X)
- Yu Zhou (ORCID: https://orcid.org/0000-0002-3065-4625)
- Xin Li (ORCID: https://orcid.org/0000-0003-0553-0767)
- Qiuping Zhang (ORCID: https://orcid.org/0009-0003-3816-4756)
Institutions
- Royal National Orthopaedic Hospital (GB)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Municipal Health Commission (CN)
- First People's Hospital of Chongqing (CN)
- University College London (GB)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Mediators of Inflammation
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1155/mi/2808908
- Primary Topic
- Bone and Joint Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chongqing University