NEDD4L knockdown reduced lipid accumulation in non-alcoholic fatty liver disease by promoting the activity of PI3K/AKT signaling pathway
NEDD4L knockdown increased the PI3K/AKT signaling pathway activity, leading to decreased lipid accumulation in NAFLD. Therefore, NEDD4L appears to be a useful target for NAFLD diagnosis and management.
Authors
- Dingchun Li
- Zhiwen Duan
- Chunxia Yang
- Wu Li (ORCID: https://orcid.org/0000-0003-3942-0515)
- Ju Zhou (ORCID: https://orcid.org/0000-0003-0185-3366)
- Xiaowei Chi (ORCID: https://orcid.org/0000-0003-1788-8045)
Institutions
- Kunming Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1186/s40001-025-03620-1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00